Faculty of Medicine, Dentistry and Health Sciences

Available projects

R102: Incidence and predictors of coronary atherosclerosis in patients with familial hypercholesterolemia

This option is flagged and requires special approval, See details below.

Department:
Medicine and Pharmacology

Primary Supervisor: Tim Bates	Primary Supervisor Email: timothy.bates@health.wa.gov.au

Administrative Assistant:	Administrative Assistant Phone:

Maximum number of students:
3

Project Outline:
Patients with familial hypercholesterolemia have an increased risk of premature coronary atherosclerosis. This risk though is variable and may be modified by treatment, particularly with statins. In this project we seek to define the incidence of coronary artery disease (coronary stenosis extent and coronary calcium scores) in genetically proven FH, as well the predictors of such coronary artery disease. The predictors to be evaluated include traditional risk factors, metabolic markers including apolipoproteins, Lp (a) and mutations found. The patients will be sourced from the FHWA database with the imaging being available on the WA PACS database.

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