Faculty of Health and Medical Sciences

Tissue Repair Group

 

Dr. Cecilia Prêle

Laboratory:
Tissue Repair Group
Location:
Harry Perkins Institute of Medical Research

Websites:

Fibrotic lung tissue. Image provided by A/Prof Mutsaers.


Area of Expertise

Research projects within the Tissue Repair Group are run jointly between CCTRM and the Institute for Respiratory Health. The team has two main focuses 1) To interrogate the molecular pathways driving idiopathic pulmonary fibrosis and mesothelioma and 2) investigate the mechanisms responsible for serosal repair. Recently Dr. Prêle and her team have partnered with Dr. Mark Fear, Prof. Fiona Wood (UWA) and Prof. Robin McAnulty (UCL) to investigate common pathways and mechanisms driving fibrosis in lung and skin (supported by a NHMRC Project Grant and BLF Funding). A/Prof. Mutsaers, Dr. Prêle and Prof. Sam Janes (UCL), have established a collaboration to investigate the therapeutic benefit of hedgehog signalling inhibition on malignant mesothelioma (funded by BLF, Maurice Blackburn Award). This group combines the analysis of patient clinical samples with mechanistic analysis performed in preclinical models of disease. 


Top 5 Recent Publications

  1. Lansley SM, Pedersen B, Robinson C, Searles RG, Sterrett G, van Bruggen I, Lake RA, Mutsaers SE and Prele CM. A Subset of Mesothelioma Tumors Retain Osteogenic Potential. Sci Rep. 2016, 6:36349
  2. Birnie KA, Yip YY, Ng DCH, Kirschner MB, Reid G, Prêle CM, Musk AW, Lee YCG, Thompson PJ, Mutsaers SE, Badrian B.. Loss of microRNA-223 and c-Jun N-terminal kinase (JNK) signalling contribute to the over-expression of Stathmin in Malignant Pleural Mesothelioma. Mol Cancer Research. Mol Cancer Res. 2015 Jul;13(7):1106-18.
  3. Lim CB, Prêle CM, Arthur PG, Baltic S, Creaney J, Watkins DN, Thompson PJ and Mutsaers SE, Mitochondria-derived reactive oxygen species drives GANT61-induced malignant mesothelioma cell apoptosis. Oncotarget 2015 Jan 30;6(3):1519-30.
  4. Lim CB, Prêle CM, Cheah HM, Cheng YY, Klebe S, Reid G, Watkins DN, Baltic S, Thompson PJ, Mutsaers SE. Mutational analysis of Hedgehog signaling pathway genes in human malignant mesothelioma PLoS One. 2013 Jun 24;8(6):e66685.
  5. O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE. Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. EMBO Mol Med. 2012; 4(9):939-51.


Publications with CCTRM byline

Articles

  1. Jaffar J, Unger S, Corte TJ, Keller M, Wolters PJ, Richeldi L, Cerri S, Prêle CM, Hansbro PM, Argraves WS, Oliver RA, Oliver BG, Black JL, Burgess JK. Fibulin-1 predicts disease progression in patients with pulmonary fibrosis. Chest. 2014 Oct 146(4):1055-63.
  2. Lim CB, Prêle CM, Arthur PG, Baltic S, Creaney J, Watkins DN, Thompson PJ and Mutsaers SE, Mitochondria-derived reactive oxygen species drives GANT61-induced malignant mesothelioma cell apoptosis. Oncotarget 2015 Jan 30;6(3):1519-30.
  3. Birnie KA, Yip YY, Ng DCH, Kirschner MB, Reid G, Prêle CM, Musk AW, Lee YCG, Thompson PJ, Mutsaers SE, Badrian B.. Loss of microRNA-223 and c-Jun N-terminal kinase (JNK) signalling contribute to the over-expression of Stathmin in Malignant Pleural Mesothelioma. Mol Cancer Research. Mol Cancer Res. 2015 Jul;13(7):1106-18.
  4. André PA, Prêle CM, Chambers R, Carnesecchi-Acker S, Donati Y, Pache JC, Crestani B, Barazzone C, Laurent GJ, Irminger-Finger I. BARD1 in pulmonary fibrosis: novel putative mediator downstream of TGF-β activation. Respir Res. 2015 Sep 29;16:118.
  5. Lansley SM, Pedersen B, Robinson C, Searles RG, Sterret G, van Bruggen I, Lake R, Mutsaers SE, Prêle CM. A Subset of Malignant Mesothelioma Tumors Retain Osteogenic Potential. Scientific Reports. 2016 Nov 25;6:36349

Review Articles

  1. McQualter JL, Anthony D, Prêle CM, Laurent GJ. Harnessing the potential of adult lung stem cells for regenerative medicine. Invited Review Int J Biochem Cell Biol. 2014 Nov 56:82-91.
  2. Mutsaers SE, Birnie K, Lansley S, Herrick SE, Lim CB, Prêle CM. Mesothelial cells in tissue repair and fibrosis. Front Pharmacol. 2015 Jun 9;6:113.
  3. Mutsaers SE, Prêle CM, Pengally S, Herrick SE. Mesothelial Cell Homeostasis. Fertility and Sterility 2016; 106(5):1018-1024.
  4. Hoyne GF, Elliott H, Mutsaers SE, Prêle CM. Idiopathic pulmonary fibrosis: the role of innate and adaptive immunity. Immunol Cell Biol. 2017 Mar 30. doi: 10.1038/icb.2017.22. (in press)

Book Chapters

  1. Mutsaers SE, Jaurand MC, Lee YC, Prêle CM. Chapter 3. Mesothelial Cells and Pleural  
    Immunology. Textbook of pleural diseases Ed 3. Ed R Light and YC G Lee. 2016: p27-44
  2. Mutsaers SE, Prêle CM and Herrick SE. Chapter 5.  Structure and function of the mesothelial  cell. Intraperitoneal Cancer Therapy: Principles and Practice Ed W.P Ceelen. 2015:9-15.


Recent Grant Successes

  1. **2017-2020 NHMRC Project Grant – Epithelial-mesenchymal cell communication; towards new therapeutic targets for fibrosis – Prêle CM, Knight D, Fear M, McAnulty R, Wood F  and Laurent G. $794,596
  2. 2017-2019 British Lung Foundation. PhD Scholarship Grant – Investigating Gli as a novel therapeutic target in malignant mesothelioma. Janes S, McAnulty R, Mutsaers S, Prêle CM.  £100,000 ($160,852)
  3. 2016-2019 NHMRC Project Grant - Fibroblast Scenecence as a diver of pulmonary fibrosis – Knight D, Burgess J, Westall G, Laurent G, Mutsaers S, Prêle CM. $845,611
  4. **2015-2017 British Lung Foundation. Pump Priming Grant. McAnulty R, Mutsaers S, Prêle CM. Evaluating B-cell and JAK/STAT targeted therapies for lung fibrosis. £25,000 ($43,227)
  5. *2014-2017 NHMRC Project Grant 1067511- STAT3 regulation of cell responses in IPF 1067511 Prêle CM, Mutsaers, Knight, O'Donoghue, Hoyne, Laurent $650,558
  6. **2016-2017 UHU Seed Funding Grant - Investigating HGF-induced STAT6 signaling in stromal-epithelial cell crosstalk. Janes S, Prêle CM, Hynds R £6,280 ($10,859)
  7. **2016-2017 UHU Seed Funding Grant - Can the rejuvenation of IGF-1 levels restore the   capacity for lung regeneration? Lucas A, Giangreco A, Prêle CM $15,000
  8. 2017  Maurice Blackburn Grant - GANT61: A novel therapy for malignant mesothelioma. Mutsaers SE, Prele CM and Janes S. $20,000
  9. 2015-2016 SCGH RAC Grant Chakera A, Carson C, Prêle CM, Mutsaers SE Systematic analysis of the effect of infection on mesothelial gene transcription: implications for the management of peritoneal dialysis-associated peritonitis. $49,945
  10. *2015 Commercial Funding from Cynata Therapeutics. Laurent GJ, Prêle CM. $72,207
  11. *2014-2015 Sir Charles Gairdner Hospital Research Advisory Committee Grant Role of IGF1 and IGF1R signalling in compensatory lung growth post pneumonectomy. Lucas, Laurent, Prêle, Mutsaers, Eule, Delriviere  $40,000
  12. 2012-2013  Raine Priming Grant - Regulation of SOCS1 gene expression in lung fibrosis – CI Prêle, AI Mutsaers, AI Jamieson $110,000

*CCTRM affiliated grants

**CCTRM and UHU affiliated grants


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