Faculty of Health and Medical Sciences

Molecular Laboratory

 

W/Prof. Jiake Xu

Laboratory:
Molecular Laboratory
Location:
M Block, QEII Medical Centre, Nedlands
Website:

https://www.web.uwa.edu.au/people/jiake.xu


Area of Expertise

  • Osteoimmunology, osteolysis, and mechanisms of bone resorption.
  • Bone marrow-derived mesenchymal stem cells and pericytes.
  • Screening of natural compounds for the treatment of osteoporosis.
  • Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice.
  • Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment.

Top 5 Recent Publications

  1. Liang C,  Guo B, Wu H, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau W, Yang Z, Lu C, He X, Au DWT, Pan X, Zhang B, Lu C, Zhang H, Yue K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W,  Liang Z, He F, Zhang L, Lu A, Zhang G. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med. 2015 Mar;21(3):288-94.
  2. Rea SL, Walsh JP, Layfield R, Ratajczak T, Xu J*. (2013) New insights into the role of Sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone. Endocr Rev. 2013 34(4):501-24.  (*Corresponding author). 
  3. Zhou L, Liu Q, Yang M, Wang T, Yao J, Cheng J, Yuan J, Lin X, Zhao J, Tickner J, Xu J*. Dihydroartemisinin, an anti-malaria drug, suppresses estrogen deficiency-induced osteoporosis, osteoclast formation and RANKL induced signalling pathways. J Bone Miner Res. 2016 May;31(5):964-74. doi: (*Corresponding author).
  4. Zhou C, You Y, Peng J, Feng H, Wang Y, Li D, Shao WW, Li CX, Li WZ, Xu J*, Shen X*. Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation. Ann Rheum Dis. 2016 Jun;75(6):1211-8. (*Co-corresponding author).
  5. Kular J, Tickner JC, Pavlos NJ, Viola HM, Abel T, Lim BS, Yang X, Chen H, Cook R, Hool LC, Zheng MH, Xu J*. (2015) Choline Kinase Beta Mutant Mice Exhibit Reduced Phosphocholine, Elevated Osteoclast Activity and Low Bone Mass. J Biol Chem. 16;290(3):1729-42.. (*Corresponding author).


Recent Grant Successes

  1. Professor Cory Xian, Associate Professor Bruce Foster, Winthrop Professor Jiake Xu 2017, 'NT-3 as an upstream and potentially master regulator promoting bone fracture healing', University of South Australia ex NHMRC. 
  2. Winthrop Professor Jiake Xu, Associate Professor Nathan Pavlos, Dr Jennifer Tickner, Dr Scott Wilson, Dr John Walsh 2016, 'Gene mining for novel molecular determinants of the skeleton', NHMRC Project Grants. 
  3. Winthrop Professor Jiake Xu, Professor Renxiang Tan 2016, 'Molecular Mechanisms and therapeutic effects of cumambrin A on osteoporosis', UWA Research Collaboration Awards. 
  4. Winthrop Professor Jiake Xu 2016, 'Molecular Mechanisms and Therapeutic Effects of Carnosol on Collagen-induced Arthritis and Osteolysis', Arthritis Foundation of Australia. 
  5. Winthrop Professor Jiake Xu, Associate Professor Nathan Pavlos, Dr Jennifer Tickner 2015, 'Furin: Carving-up vital substrates for bone remodelling and homeostasis', NHMRC Project Grants. 
  6. Winthrop Professor Jiake Xu 2015, 'MHRIF Round 19 - Jiake Xu', Medical & Health Research Infrastructure Fund. 
  7. Winthrop Professor Jiake Xu, Professor Renxiang Tan 2014, 'Molecular Mechanisms and therapeutic effects of Parthenolide analogues on bone and joint diseases', UWA Research Collaboration Awards. 
  8. Dr Paul Leo, Dr Jennifer Tickner, Associate Professor Emma Duncan, Professor Matthew Brown, Dr Scott Wilson, Mr Benjamin Mullin, Winthrop Professor Jiake Xu 2014, 'Identification of novel molecules that regulate bone homeostasis using ENU-induced mutant mice models, and human genome-wide association studies and massive parallel sequencing', UWA UQ Bilateral Research Collaboration Award. 
  9. Winthrop Professor Jiake Xu 2014, 'MHRIF Round 18 - Xu, Jiake', Medical & Health Research Infrastructure Fund. 
  10. Winthrop Professor Jiake Xu 2013, 'Molecular Mechanisms and Therapeutic Effects of Helenalin on Collagen-induced Arthritis and Osteolysis', Arthritis Foundation of Australia. 
  11. Winthrop Professor Jiake Xu 2012, 'Therapeutic effects of natural compounds on bone and joint diseases', UWA Research Collaboration Awards. 
  12. Winthrop Professor Jiake Xu 2012, 'Round 16 - Xu', Medical & Health Research Infrastructure Fund. 
  13. Winthrop Professor Jiake Xu 2012, 'The Therapeutic Effect an Mechanism of Actions of Natural Compounds in Bone Health', Nestec Ltd.

Back to top