Faculty of Health and Medical Sciences

Liver Disease and Regeneration Laboratory

 

Dr. Nina Tirnitz-Parker

Laboratory:
Liver Disease and Regeneration Laboratory
Location:
School of Pharmacy and Biomedical Sciences, and Curtin Health Innovation Research Institute, Curtin University
Website:
https://oasisapps.curtin.edu.au/staff/profile/view/N.Tirnitz-Parker

Pan Cytokeratin+ cholangiocarcinoma cells (PCK; green) express monocyte chemoattractant protein-1 (MCP-1; red) to attract CD68+ macrophages (white) to the tumour Niche (image courtesy of Ben Dywer)


Area of Expertise

  • Liver progenitor cells, stem cells, cancer stem cells
  • Cytokine and chemokine signalling
  • Liver fibrosis, hepatocellular carcinoma, cholangiocarcinoma
  • Tissue engineering and regenerative medicine

  • Top 5 Recent Publications

    1. Kohn-Gaone J, Dwyer BJ, Grzelak CA, Miller G, Shackel NA, Ramm GA, McCaughan GW, Elsegood CL, Olynyk JK, Tirnitz-Parker JE.Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury.Am J Pathol. 2016 Jul;186(7):1762-74.
    2. Kohn-Gaone J, Gogoi-Tiwari J, Ramm GA, Olynyk JK, Tirnitz-Parker JE. The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 1;310(3):G143-54.
    3. Muller M, Wetzel S, Kohn-Gaone J, Chalupsky K, Lullmann-Rauch R, Barikbin R, Bergmann J, Wohner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D. A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis. Oncotarget. 2016 Apr 5;7(14):17431-41.
    4. Dwyer BJ, Olynyk JK, Ramm GA, Tirnitz-Parker JE. TWEAK and LT? Signaling during Chronic Liver Disease. Front Immunol. 2014 Feb 13;5:39.
    5. Grzelak CA, Martelotto LG, Sigglekow ND, Patkunanathan B, Ajami K, Calabro SR, Dwyer BJ, Tirnitz-Parker JE, Watkins DN, Warner FJ, Shackel NA, McCaughan GW. The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury. J Hepatol. 2014 Jan;60(1):143-51.



    Recent Grant Successes

    1. NHMRC Project Grant APP1087125, 2015-2017, CIA Ramm, CIB Olynyk, CIC Tirnitz-Parker ($299,577 to CIC)
    2. NHMRC Equipment Grant APP1087125, 2015, CIA Tirnitz-Parker ($23,810)
    3. NHMRC Project Grant APP1031330, 2012-2014, CIA Ramm, CIB Olynyk, CIC Tirnitz-Parker ($299,843 to CIC)
    4. ARC LIEF Grant LE170100225, 2017, $410,000, CI
    5. ARC LIEF Grant LE150100066, 2015, $440,000, CI.
    6. Fremantle Hospital Medical Research Foundation and Curtin University Equipment Grant, 2015, $110.000
    7. Fremantle Hospital Medical Research Foundation Grant 2015, $15,000
    8. ATN-DAAD Joint Research Co-Operation Scheme Research Grant, 2015-2017, $23,600
    9. Government of Western Australia, New Independent Researcher Infrastructure Support Grant, 2014, $10,000
    10. AW Morrow Gastroenterology and Liver Centre, Collaborative Research Grant, 2012-2020, $100.000
    11. Fremantle Hospital Medical Research Foundation Grant 2012, $15,000

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